Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability

• Main Authors: Yi Cheng (Author), Chie Watanabe (Author), Yusuke Ando (Author), Satoshi Kitaoka (Author), Yuya Egawa (Author), Tomoya Takashima (Author), Akihiro Matsumoto (Author), Masahiro Murakami (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The intestinal epithelial Caco-2 cell monolayer is a well-established in vitro model useful for predicting intestinal drug absorption in humans. Coculture models of Caco-2 and goblet-cell-like HT29-MTX cells have been developed to overcome the lack of a mucus layer; however, those models are much le...