Preparation of chitosan-coated hollow tin dioxide nanoparticles and their application in improving the oral bioavailability of febuxostat

• Main Authors: Junpeng Sun (Author), Jiaqun Du (Author), Xiaobang Liu (Author), Jinyu An (Author), Yingqiao Li (Author), Yanan Yu (Author), Minghui Li (Author), Li Zheng (Author), Chao Wu (Author), Lili Hu (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to design a chitosan-coated hollow tin dioxide nanosphere (CS-HSn) for loading febuxostat (FEB) using an adsorption method to obtain a sustained-release system (CS-HSn-FEB) to improve the oral bioavailability of FEB. The morphological characteristics of hollow tin dioxide n...