Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production

• Główni autorzy: Jie Zhu (Autor), Michael R. Edwards (Autor), Simon D. Message (Autor), Luminita A. Stanciu (Autor), Sebastian L. Johnston (Autor), Peter K. Jeffery (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

<b>Background:</b> Cilomilast, a phosphodiesterase-4 (PDE4) selective inhibitor, has anti-inflammatory effects in vitro and in vivo and reduces COPD exacerbations. We tested the hypothesis that cilomilast inhibits virus-induced airway epithelial intercellular adhesion molecule-1 (ICAM-1)...