Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? <it>Design of a case-control study</it>

• Main Authors: Cornel Martina C (Author), Kuik Dirk J (Author), Heutink Peter (Author), Bochdanovits Zoltan (Author), Henneman Lidewij (Author), Teeuw Marieke E (Author), ten Kate Leo P (Author)
• Format: Book
• Published: BMC, 2010-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The offspring of consanguineous relations have an increased risk of congenital/genetic disorders and early mortality. Consanguineous couples and their offspring account for approximately 10% of the global population. The increased ri...