Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease

• Main Authors: Antonio Munafò (Author), Anna Flavia Cantone (Author), Giulia Di Benedetto (Author), Sebastiano Alfio Torrisi (Author), Chiara Burgaletto (Author), Carlo Maria Bellanca (Author), Gabriella Gaudio (Author), Giuseppe Broggi (Author), Rosario Caltabiano (Author), Gian Marco Leggio (Author), Renato Bernardini (Author), Giuseppina Cantarella (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly population worldwide. Due to the multifactorial nature of the disease, involving impairment of cholinergic neurotransmission and immune system, previous attempts to find effective treatmen...