Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy

• Main Authors: Ningyan Hu (Author), Eunjoo Kim (Author), Layal Antoury (Author), Jia Li (Author), Paloma González-Pérez (Author), Seward B. Rutkove (Author), Thurman M. Wheeler (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with myotonic dystrophy type 1 (DM1) identify chronic fatigue as the most debilitating symptom, which manifests in part as prolonged recovery after exercise. Clinical features of DM1 result from pathogenic gain-of-function activity of transcripts containing an expanded microsatellite CUG re...