Targeting tRNA-synthetase interactions towards novel therapeutic discovery against eukaryotic pathogens.

• Main Authors: Paul Kelly (Author), Fatemeh Hadi-Nezhad (Author), Dennis Y Liu (Author), Travis J Lawrence (Author), Roger G Linington (Author), Michael Ibba (Author), David H Ardell (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of chemotherapies against eukaryotic pathogens is especially challenging because of both the evolutionary conservation of drug targets between host and parasite, and the evolution of strain-dependent drug resistance. There is a strong need for new nontoxic drugs with broad-spectrum a...