Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

• Päätekijät: Iain D Kerr (Tekijä), Peng Wu (Tekijä), Rachael Marion-Tsukamaki (Tekijä), Zachary B Mackey (Tekijä), Linda S Brinen (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in the progres...