Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

• Main Authors: Iain D Kerr (Author), Peng Wu (Author), Rachael Marion-Tsukamaki (Author), Zachary B Mackey (Author), Linda S Brinen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma brucei is the etiological agent of Human African Trypanosomiasis, an endemic parasitic disease of sub-Saharan Africa. TbCatB and rhodesain are the sole Clan CA papain-like cysteine proteases produced by the parasite during infection of the mammalian host and are implicated in the progres...