Pharmacokinetics, pharmacodynamics, and safety of GS‐3583, a FLT3 agonist Fc fusion protein, from single‐ascending‐dose phase I study in healthy participants

• Главные авторы: Anees M. Dauki (Автор), Nishanthan Rajakumaraswamy (Автор), Torsten Trowe (Автор), Winnie Weng (Автор), Kai‐Wen Lin (Автор), Emon Elboudjwarej (Автор), Ann Ran‐Ran Qin (Автор), Christian Schwabe (Автор), Michelle R. Kuhne (Автор), Ahmed A. Othman (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2024-08-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor‐specific CD8+ T cells and their recruitment to tumor microenvironment. However, cDC1s are often underrepresented in the microenvironment. Systemic administration of Fms‐like tyrosine kinase...