Pharmacokinetics, pharmacodynamics, and safety of GS‐3583, a FLT3 agonist Fc fusion protein, from single‐ascending‐dose phase I study in healthy participants

• Main Authors: Anees M. Dauki (Author), Nishanthan Rajakumaraswamy (Author), Torsten Trowe (Author), Winnie Weng (Author), Kai‐Wen Lin (Author), Emon Elboudjwarej (Author), Ann Ran‐Ran Qin (Author), Christian Schwabe (Author), Michelle R. Kuhne (Author), Ahmed A. Othman (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor‐specific CD8+ T cells and their recruitment to tumor microenvironment. However, cDC1s are often underrepresented in the microenvironment. Systemic administration of Fms‐like tyrosine kinase...