Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress

• Egile Nagusiak: Shunhao Zhang (Egilea), Sining Duan (Egilea), Zhuojun Xie (Egilea), Wanlin Bao (Egilea), Bo Xu (Egilea), Wenbin Yang (Egilea), Lingyun Zhou (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in redox homeostasis, which protects cells from stress conditions such as reactive oxygen species and therefore exerts be...