Early evidence of delayed oligodendrocyte maturation in the mouse model of mucolipidosis type IV

• Hlavní autoři: Molly Mepyans (Autor), Livia Andrzejczuk (Autor), Jahree Sosa (Autor), Sierra Smith (Autor), Shawn Herron (Autor), Samantha DeRosa (Autor), Susan A. Slaugenhaupt (Autor), Albert Misko (Autor), Yulia Grishchuk (Autor), Kirill Kiselyov (Autor)
• Médium: Kniha
• Vydáno: The Company of Biologists, 2020-07-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Mucolipidosis type IV (MLIV) is a lysosomal disease caused by mutations in the MCOLN1 gene that encodes the endolysosomal transient receptor potential channel mucolipin-1, or TRPML1. MLIV results in developmental delay, motor and cognitive impairments, and vision loss. Brain abnormalities include th...