Notch3 Targeting: A Novel Weapon against Ovarian Cancer Stem Cells

• Main Authors: Simona Ceccarelli (Author), Francesca Megiorni (Author), Diana Bellavia (Author), Cinzia Marchese (Author), Isabella Screpanti (Author), Saula Checquolo (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models. Several studies demonstrate that Notch3 expression renders cancer cells more resistant to carbopla...