Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells

• Main Authors: Aram M. de Haas (Author), Dorian A. Stolk (Author), Sjoerd T. T. Schetters (Author), Laura Goossens-Kruijssen (Author), Eelco Keuning (Author), Martino Ambrosini (Author), Louis Boon (Author), Hakan Kalay (Author), Gert Storm (Author), Hans J. van der Vliet (Author), Tanja D. de Gruijl (Author), Yvette van Kooyk (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide, along with a DC-SIGN-targeting ligand, Lewis Y (Le<sup>...