Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells

• Main Authors: Anqi Wang (Author), Jiayu Liu (Author), Yuhan Yang (Author), Zhejie Chen (Author), Caifang Gao (Author), Zhanguo Wang (Author), Chaomei Fu (Author), Liang Zou (Author), Shengpeng Wang (Author)
• Format: Book
• Published: BMC, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Shikonin (SKO) is a natural naphthoquinone derived from Chinese herbal medicine Arnebiae Radix with high development potentials due to its anti-inflammatory and anti-tumor activities. Overwhelming evidences have indicated that SKO can induce both necrosis and apoptosis in cancer...