Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

• Main Authors: Emilia Sawicki (Author), Michel J. Hillebrand (Author), Hilde Rosing (Author), Jan H.M. Schellens (Author), Bastiaan Nuijen (Author), Jos H. Beijnen (Author)
• Formato: Livro
• Publicado em: Elsevier, 2016-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as P-glycoprotein and Breast Cancer Resistance Protein. Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve...