Morin hydrate downregulates inflammation‐mediated nitric oxide overproduction and potentiates antioxidant mechanism against anticancer drug doxorubicin oxidative hepatorenal toxicity in rats

• Auteurs principaux: Ademola Famurewa (Auteur), Chima Ekeleme-Egedigwe (Auteur), Patience Ogbu (Auteur), Ayodeji Ajibare (Auteur), Moshood Folawiyo (Auteur), Doris Obasi (Auteur), Arunaksharan Narayanankutty (Auteur)
• Format: Livre
• Publié: Mashhad University of Medical Sciences, 2023-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats.Materials and Methods: There were 4 groups of rats...