Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics

• Main Authors: Jian Gao (Author), Zhigui Wu (Author), Mingxia Zhao (Author), Rui Zhang (Author), Manru Li (Author), Dongdong Sun (Author), Haibo Cheng (Author), Xianjia Qi (Author), Yuxian Shen (Author), Qiang Xu (Author), Hongqi Chen (Author), Dijun Chen (Author), Yang Sun (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was perform...