Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Quality-by-Design-Based Development of a Voxelotor Self-Nanoemulsifying Drug-Delivery System with Improved Biopharmaceutical Attributes

Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surfactants, and cosurfactants were screened for their...

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Main Authors: Aristote B. Buya (Author), Romano Terrasi (Author), Jérémie K. Mbinze (Author), Giulio G. Muccioli (Author), Ana Beloqui (Author), Patrick B. Memvanga (Author), Véronique Préat (Author)
Format: Book
Published: MDPI AG, 2021-09-01T00:00:00Z.
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