Pharmacokinetic Variability in Pre-Clinical Studies: Sample Study with Abiraterone in Rats and Implications for Short-Term Comparative Pharmacokinetic Study Designs

• Main Authors: Jana Královičová (Author), Aleš Bartůněk (Author), Jiří Hofmann (Author), Tomáš Křížek (Author), Petr Kozlík (Author), Jaroslava Roušarová (Author), Pavel Ryšánek (Author), Martin Šíma (Author), Ondřej Slanař (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One of the major concerns for all in vivo experiments is intra- and inter-subject variability, which can be a great source of inaccuracy. The aim of this study is, therefore, to estimate the ability of parallel vs. cross-over design studies in order to describe the relative pharmacokinetic performan...