Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish

• Main Authors: Hunter LeCorgne (Author), Andrew M. Tudosie (Author), Kari Lavik (Author), Robin Su (Author), Kathryn N. Becker (Author), Sara Moore (Author), Yashna Walia (Author), Alexander Wisner (Author), Daniel Koehler (Author), Arthur S. Alberts (Author), Frederick E. Williams (Author), Kathryn M. Eisenmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mammalian Diaphanous-related (mDia) formins are cytoskeletal regulators that assemble and, in some cases, bundle filamentous actin (F-actin), as well as stabilize microtubules. The development of small molecule antagonists and agonists that interrogate mDia formin function has allowed us to inve...