Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

• Main Authors: Omar S. Al-Odat (Author), Max von Suskil (Author), Robert J. Chitren (Author), Weam O. Elbezanti (Author), Sandeep K. Srivastava (Author), Tulin Budak-Alpddogan (Author), Subash C. Jonnalagadda (Author), Bharat B. Aggarwal (Author), Manoj Pandey (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis of MM. Thus, inhibit...