Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®

• Main Authors: Vasilios Liapis (Author), William Tieu (Author), Stacey E. Rudd (Author), Paul S. Donnelly (Author), Nicole L. Wittwer (Author), Michael P. Brown (Author), Alexander H. Staudacher (Author)
• 格式: 图书
• 出版: SpringerOpen, 2020-11-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract Purpose The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but only becomes available for antibody binding in dead tumor cells. Hence, chDAB4 may be used as a novel theranostic tool to...