Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease.

• Main Authors: Nisha Jain Garg (Author), Kizhake V Soman (Author), Maria P Zago (Author), Sue-Jie Koo (Author), Heidi Spratt (Author), Susan Stafford (Author), Zinzi N Blell (Author), Shivali Gupta (Author), Julio Nuñez Burgos (Author), Natalia Barrientos (Author), Allan R Brasier (Author), John E Wiktorowicz (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi (Tc) infection causes chagasic cardiomyopathy; however, why 30-40% of the patients develop clinical disease is not known. To discover the pathomechanisms in disease progression, we obtained the proteome signature of peripheral blood mononuclear cells (PBMCs) of normal healthy contr...