Bridging the structure gap between pellets in artificial dissolution media and in gastro-intestinal tract in rats

• Main Authors: Hongyu Sun (Author), Siyu He (Author), Li Wu (Author), Zeying Cao (Author), Xian Sun (Author), Mingwei Xu (Author), Shan Lu (Author), Mingdi Xu (Author), Baoming Ning (Author), Huimin Sun (Author), Tiqiao Xiao (Author), Peter York (Author), Xu Xu (Author), Xianzhen Yin (Author), Jiwen Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Changes in structure of oral solid dosage forms (OSDF) elementally determine the drug release and its therapeutic effects. In this research, synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3D structure of enteric coated pellets recovered from the gastrointestinal...