Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies

• Main Authors: Anna Mueller-Schoell (Author), Lena Klopp-Schulze (Author), Robin Michelet (Author), Madelé van Dyk (Author), Thomas E. Mürdter (Author), Matthias Schwab (Author), Markus Joerger (Author), Wilhelm Huisinga (Author), Gerd Mikus (Author), Charlotte Kloft (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C_{SS,min ENDX}) above 5.97 ng/mL have been associated with favourable disease outcome. Yet, about 20% of patients do not reach target C<sub>SS,mi...