Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies
Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C<sub>SS,min ENDX</sub>) above 5.97 ng/mL have been associated with favourable disease outcome. Yet, about 20% of patients do not reach target C<sub>SS,mi...
Saved in:
Main Authors: | Anna Mueller-Schoell (Author), Lena Klopp-Schulze (Author), Robin Michelet (Author), Madelé van Dyk (Author), Thomas E. Mürdter (Author), Matthias Schwab (Author), Markus Joerger (Author), Wilhelm Huisinga (Author), Gerd Mikus (Author), Charlotte Kloft (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2021-02-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen
by: Lena Klopp-Schulze, et al.
Published: (2020) -
Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen
by: Werner Schroth, et al.
Published: (2017) -
The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer
by: Jeanine Marie Nardin, et al.
Published: (2020) -
Auraptene Boosts the Efficacy of the Tamoxifen Metabolites Endoxifen and 4-OH-Tamoxifen in a Chemoresistant ER+ Breast Cancer Model
by: Angel Pulido-Capiz, et al.
Published: (2024) -
Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen
by: Anna Benedykcinska, et al.
Published: (2016)