Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against <i>Pseudomonas aeruginosa</i> for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model

• Main Authors: Jessica R. Tait (Author), Hajira Bilal (Author), Kate E. Rogers (Author), Yinzhi Lang (Author), Tae-Hwan Kim (Author), Jieqiang Zhou (Author), Steven C. Wallis (Author), Jürgen B. Bulitta (Author), Carl M. J. Kirkpatrick (Author), David L. Paterson (Author), Jeffrey Lipman (Author), Phillip J. Bergen (Author), Jason A. Roberts (Author), Roger L. Nation (Author), Cornelia B. Landersdorfer (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated piperacillin-tazobactam and tobramycin regimens against <i>Pseudomonas aeruginosa</i> isolates from critically ill patients. Static-concentration time-kill studies (SCTK) assessed piperacillin-tazobactam and tobramycin monotherapies and combinations against four isolates ove...