Development and characterization of a reverse genetic system for studying dengue virus serotype 3 strain variation and neutralization.

• Main Authors: William B Messer (Author), Boyd Yount (Author), Kari E Hacker (Author), Eric F Donaldson (Author), Jeremy P Huynh (Author), Aravinda M de Silva (Author), Ralph S Baric (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue viruses (DENV) are enveloped single-stranded positive-sense RNA viruses transmitted by Aedes spp. mosquitoes. There are four genetically distinct serotypes designated DENV-1 through DENV-4, each further subdivided into distinct genotypes. The dengue scientific community has long contended tha...