Amiodarone Provides Long-Lasting Local Anesthesia and Analgesia in Open-State Mouse Nociceptors

• Main Authors: Masakazu Kotoda (Author), Toru Matsuoka (Author), Keiichi Wada (Author), Selwyn Jayakar (Author), Hirofumi Ino (Author), Koji Kawago (Author), Yasutomo Kumakura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Local anesthetics with long-lasting effects and selectivity for nociceptors have been sought over the past decades. In this study, we investigated whether amiodarone, a multiple channel blocker, provides long-lasting local anesthesia and whether adding a TRPV1 channel activator selectively prolongs...