Rituximab pediatric drug development: Pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with granulomatosis with polyangiitis or microscopic polyangiitis

• Main Authors: Candice Jamois (Author), Leonid Gibiansky (Author), Clarisse Chavanne (Author), Melissa Cheu (Author), Patricia B. Lehane (Author), Pooneh Pordeli (Author), Simone Melega (Author), Jacques Gaudreault (Author)
• Formato: Livro
• Publicado em: Wiley, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Anti‐neutrophil cytoplasmic antibody‐associated vasculitides granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare, potentially organ‐ and life‐threatening autoimmune conditions affecting adult and pediatric patients. An open‐label phase II study was conducted t...