Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells

• Päätekijät: Tomasz Adamus (Tekijä), Chia-Yang Hung (Tekijä), Chunsong Yu (Tekijä), Elaine Kang (Tekijä), Mohamed Hammad (Tekijä), Linda Flores (Tekijä), Sergey Nechaev (Tekijä), Qifang Zhang (Tekijä), Joanna Marie Gonzaga (Tekijä), Kokilah Muthaiyah (Tekijä), Piotr Swiderski (Tekijä), Karen S. Aboody (Tekijä), Marcin Kortylewski (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2022-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and activator of transcription 3 (STAT3) protein into...