A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study

• Үндсэн зохиолчид: Lingzhi Wang (Зохиогч), Do-Dang Khoa Phan (Зохиогч), Nicholas Syn (Зохиогч), Xiaoqiang Xiang (Зохиогч), Hongyan Song (Зохиогч), Win Lwin Thuya (Зохиогч), Shili Yang (Зохиогч), Andrea Li-Ann Wong (Зохиогч), Alan Prem Kumar (Зохиогч), Wei Peng Yong (Зохиогч), Gautam Sethi (Зохиогч), Paul Chi-Lui Ho (Зохиогч), Boon Cher Goh (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2018-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

A sensitive and robust liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of nimbolide in mouse serum. Exemestane was used as the internal standard (IS). Here, we employed acetonitrile-based protein precipitation (PPT) for serum sample...