Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy

• Hlavní autoři: Yanwen Zheng (Autor), Fanhua Kong (Autor), Songyang Liu (Autor), Xi Liu (Autor), Dongni Pei (Autor), Xiongying Miao (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Triptolide (TPL) is a diterpenoid triepoxide with broad antitumor efficacy, while lack of mechanism of action, severe systemic toxicity, and poor water solubility of TPL limited its usage. To unveil the mechanism of action and improve the pharmaceutical properties of TPL, here we explored the molecu...