Synthesis and Validation of a Hydroxypyrone-Based, Potent, and Specific Matrix Metalloproteinase-12 Inhibitor with Anti-Inflammatory Activity In Vitro and In Vivo

• Hlavní autoři: J. Aerts (Autor), R. E. Vandenbroucke (Autor), R. Dera (Autor), S. Balusu (Autor), E. Van Wonterghem (Autor), L. Moons (Autor), C. Libert (Autor), W. Dehaen (Autor), L. Arckens (Autor)
• Médium: Kniha
• Vydáno: Hindawi Limited, 2015-01-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

A hydroxypyrone-based matrix metalloproteinase (MMP) inhibitor was synthesized and assayed for its inhibitory capacity towards a panel of ten different MMPs. The compound exhibited selective inhibition towards MMP-12. The effects of inhibition of MMP-12 on endotoxemia and inflammation-induced blood-...