PD-L1 diagnostic tests: a systematic literature review of scoring algorithms and test-validation metrics

• Main Authors: Margarita Udall (Author), Maria Rizzo (Author), Juliet Kenny (Author), Jim Doherty (Author), SueAnn Dahm (Author), Paul Robbins (Author), Eric Faulkner (Author)
• Format: Book
• Published: BMC, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 inter...