Population pharmacokinetic model and limited sampling strategy for clozapine using plasma and dried blood spot samples

• Κύριοι συγγραφείς: Lisanne M. Geers (Συγγραφέας), Dan Cohen (Συγγραφέας), Laura M. Wehkamp (Συγγραφέας), Hans J. van Wattum (Συγγραφέας), Jos G.W. Kosterink (Συγγραφέας), Anton J.M. Loonen (Συγγραφέας), Daan J. Touw (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: SAGE Publishing, 2022-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Background: To improve efficacy, therapeutic drug monitoring is often used in clozapine therapy. Trough level monitoring is regular, but trough levels provide limited information about the pharmacokinetics of clozapine and exposure in time. The area under the concentration time curve (AUC) is genera...