Population pharmacokinetic model and limited sampling strategy for clozapine using plasma and dried blood spot samples

• Main Authors: Lisanne M. Geers (Author), Dan Cohen (Author), Laura M. Wehkamp (Author), Hans J. van Wattum (Author), Jos G.W. Kosterink (Author), Anton J.M. Loonen (Author), Daan J. Touw (Author)
• Format: Book
• Published: SAGE Publishing, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: To improve efficacy, therapeutic drug monitoring is often used in clozapine therapy. Trough level monitoring is regular, but trough levels provide limited information about the pharmacokinetics of clozapine and exposure in time. The area under the concentration time curve (AUC) is genera...