Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis

• Main Authors: Ying Li (Author), Xiu-Liang Cui (Author), Qing-Shan Chen (Author), Jing Yu (Author), Hai Zhang (Author), Jie Gao (Author), Du-Xin Sun (Author), Guo-Qing Zhang (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Backgroud Cationic liposomes (CLs) can be used as non-viral vectors in gene transfer and drug delivery. However, the underlying molecular mechanism of its cytotoxicity has not been well elucidated yet. Methods We herein report a systems biology approach based on whole-transcriptome sequenci...