Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

• Main Authors: David Vehlow (Author), Jeremy P. H. Wong (Author), Birgit Urban (Author), Janek Weißpflog (Author), Annett Gebert (Author), Matthias Schumacher (Author), Michael Gelinsky (Author), Manfred Stamm (Author), Martin Müller (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyelectrolyte complex (PEC) nanoparticle (NP) bas...