Double Hit in Clear-Cell Renal Cell Carcinoma With Germline Pathogenic ATM Mutation and Somatic VHL Mutation

• Main Authors: Kok Hoe Chan MD (Author), Nicolas Duque Clavijo MD (Author), Gustavo Ayala MD (Author), Ryan Hall MD (Author), Curtis Wray MD (Author), Putao Cen MD (Author)
• פורמט: ספר
• יצא לאור: SAGE Publishing, 2024-10-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

While renal cell carcinoma (RCC) is often linked to smoking, obesity, and hypertension, hereditary forms also account for about 3% of RCC cases. Notably, NCCN guidelines identify 7 major hereditary syndromes associated with an increased RCC risk. Inherited mutations in DNA repair genes, such as ATM,...