Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling

• Main Authors: Xin You (Author), Jingyu Tian (Author), Hui Zhang (Author), Yunhua Guo (Author), Jing Yang (Author), Chaofeng Zhu (Author), Ming Song (Author), Peng Wang (Author), Zexian Liu (Author), John Cancilla (Author), Wenhua Lu (Author), Christophe Glorieux (Author), Shijun Wen (Author), Hongli Du (Author), Peng Huang (Author), Yumin Hu (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondrial aconitase (ACO2) is an essential enzyme that bridges the TCA cycle and lipid metabolism. However, its role in cancer development remains to be elucidated. The metabolic subtype of colorectal cancer (CRC) was recently established. We investigated ACO2's potential role in...