Acrylamide Analog as a Novel Nitric Oxide-Independent Soluble Guanylyl Cyclase Activator

• Main Authors: Masaki Nakane (Author), Teodozyi Kolasa (Author), Renjie Chang (Author), Loan N. Miller (Author), Robert B. Moreland (Author), Jorge D. Brioni (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Soluble guanylyl cyclase (sGC) is a target enzyme for endogenous nitric oxide (NO), and it converts GTP to cyclic GMP (guanosine 3',5'-cyclic monophosphate) as part of a cascade that results in physiological processes such as smooth muscle relaxation, neurotransmission, and inhibition of p...