Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

• Main Authors: Qian Zhang (Author), Ho Tsoi (Author), Shaohong Peng (Author), Pan P. Li (Author), Kwok-Fai Lau (Author), Dobrila D. Rudnicki (Author), Jacky Chi-Ki Ngo (Author), Ho Yin Edwin Chan (Author)
• Format: Book
• Published: The Company of Biologists, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pa...