Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

• Main Authors: Sara Lopes van den Broek (Author), Vladimir Shalgunov (Author), Rocío García Vázquez (Author), Natalie Beschorner (Author), Natasha S. R. Bidesi (Author), Maiken Nedergaard (Author), Gitte M. Knudsen (Author), Dag Sehlin (Author), Stina Syvänen (Author), Matthias M. Herth (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pretargeting is a promising nuclear imaging technique that allows for the usage of antibodies (Abs) with enhanced imaging contrast and reduced patient radiation burden. It is based on bioorthogonal chemistry with the tetrazine ligation-a reaction between <i>trans</i>-cyclooctenes (TCOs)...