Development of a Predictive Dosing Nomogram to Achieve PK/PD Targets of Amikacin Initial Dose in Critically Ill Patients: A Non-Parametric Approach

• Main Authors: Anne Coste (Author), Ronan Bellouard (Author), Guillaume Deslandes (Author), Laurence Jalin (Author), Claire Roger (Author), Séverine Ansart (Author), Eric Dailly (Author), Cédric Bretonnière (Author), Matthieu Grégoire (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2023-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

French guidelines recommend reaching an amikacin concentration of ≥8 × MIC 1 h after beginning infusion (C_1h), with MIC = 8 mg/L for probabilistic therapy. We aimed to elaborate a nomogram guiding clinicians in choosing the right first amikacin dose for ICU patients in septic...