Clinical Pharmacology‐Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy

• Main Authors: Elyes Dahmane (Author), Kathy Tang (Author), Jogarao V.S. Gobburu (Author), T. Joseph Mattingly II (Author), Brent N. Reed (Author), Vincent Y. See (Author), Joshuha Ayres (Author), Vijay Ivaturi (Author)
• Format: Book
• Published: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oral sotalol, used in adults for sinus rhythm control, is initiated at 80 mg b.i.d. and titrated to a maximum safe dose. The US Food and Drug Administration recommends monitoring the corrected QT interval (QTc) for at least 3 days, until steady‐state exposure of the drug is reached, before patient d...