The Transthyretin/Oleuropein Aglycone Complex: A New Tool against TTR Amyloidosis

• Main Authors: Francesco Bemporad (Author), Manuela Leri (Author), Matteo Ramazzotti (Author), Massimo Stefani (Author), Monica Bucciantini (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The release of monomers from the homotetrameric protein transthyretin (TTR) is the first event of a cascade, eventually leading to sporadic or familial TTR amyloidoses. Thus, ligands able to stabilize TTR and inhibit monomer release are subject of intense scrutiny as potential treatments against the...