Dyhidro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials

• Main Authors: Julio Alarcón-Enos (Author), Evelyn Muñoz-Núñez (Author), Margarita Gutiérrez (Author), Soledad Quiroz-Carreño (Author), Edgar Pastene-Navarrete (Author), Carlos Céspedes Acuña (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In order to find molecules of natural origin with potential biological activities, we isolate and synthesise compounds with agarofuran skeletons (epoxyeudesmanes). From the seeds of Maytenus disticha and Maytenus magellanica we obtained six dihydro-β-agarofurans, and by means of the Robinson annulat...