Skin-specific knockdown of hyaluronan in mice by an optimized topical 4-methylumbelliferone formulation

• Main Authors: Emily H. Steen (Author), Walker D. Short (Author), Hui Li (Author), Umang M. Parikh (Author), Alexander Blum (Author), Natalie Templeman (Author), Nadine Nagy (Author), Paul L. Bollyky (Author), Sundeep G. Keswani (Author), Swathi Balaji (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyaluronan (HA) is abundant in the skin; while HA can be synthesized by the synthases (HAS1-3), HAS2 is the leading contributor. Dysregulation and accumulation of HA is implicated in the pathogenesis of diseases such as keloid scarring, lymphedema and metastatic melanoma. To understand how HA synthe...