Aptamer-programmable adeno-associated viral vectors as a novel platform for cell-specific gene transfer

• Asıl Yazarlar: Francesco Puzzo (Yazar), Chuanling Zhang (Yazar), Bethany Powell Gray (Yazar), Feijie Zhang (Yazar), Bruce A. Sullenger (Yazar), Mark A. Kay (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Adeno-associated viruses (AAVs) are commonly used for in vivo gene therapy. Nevertheless, the wide tropism that characterizes these vectors limits specific targeting to a particular cell type or tissue. Here, we developed new chemically modified AAV vectors (Nε-AAVs) displaying a single site substit...