USP30: Structure, Emerging Physiological Role, and Target Inhibition

• Main Authors: Feng Wang (Author), Yu Gao (Author), Lihui Zhou (Author), Junhao Chen (Author), Zhiyan Xie (Author), Zifan Ye (Author), Yanfeng Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the USP subfamily, which was found localized in the mitochondrial outer membrane and peroxisomes owing to its unique transmembrane domain. Structural study revealed that USP30 employed a unique catalytic triad and...